510

EsoDant 510 is a broad-spectrum, water-soluble preservative blend of DMDM Hydantoin and the Methylchloroisothiazolinone / Methylisothiazolinone (3 : 1) system. The two chemistries act by independent mechanisms and are strongly synergistic: the formaldehyde donor provides sustained activity against Gram-negative and Gram-positive bacteria, while the isothiazolinone component delivers rapid kill at very low concentration against yeast, mould and organisms that have adapted to formaldehyde donors.

The combination gives dependable, cost-effective preservation at low use levels. EsoDant 510 is intended for rinse-off personal care products and for home care and industrial formulations; it is not permitted in leave-on cosmetics in the European Union or Japan.

• Strong broad-spectrum efficacy against bacteria, yeast and mould
• Two independent modes of action in a single, synergistic blend
• Active against formaldehyde-resistant and isothiazolinone-resistant organisms
• Very low cost-in-use
• Vapour-phase activity from the formaldehyde donor component
• Fully effective in anionic, cationic and non-ionic systems
• Clear, colourless aqueous liquid – easy to handle, dose and incorporate
• Soluble in water and compatible with most common raw materials
• Suitable for neutral-pH rinse-off applications

Personal Care – rinse-off only

• Shampoos and conditioners
• Body washes and shower gels
• Liquid hand soaps
• Makeup removers
• Rinse-off hair treatments
• Face and body scrubs

Home Care & Industrial

• Manual dishwash liquids
• Laundry detergents
• Fabric softeners
• Surface and floor cleaners
• Window / glass cleaners
• Industrial cleaning formulations

Typical use levels

EsoDant 510 is typically used at 0.10 – 0.40 % by weight in rinse-off personal care products and at 0.03 – 0.20 % in home care formulations. In the European Union the use level must not exceed 0.48 %, which corresponds to the maximum permitted CMIT / MIT concentration of 0.0015 % in the ready-to-use rinse-off product. Confirm efficacy and stability in use by challenge testing.

Addition to the formulation

Easily incorporated into water-based systems. Add as late as possible in the production process, into the water phase or the finished batch, under good agitation.

Effect of temperature

The maximum manufacturing temperature is 40 °C. The isothiazolinone component degrades progressively above this temperature. Where a process requires heating, add EsoDant 510 only after the batch has cooled below 40 °C.

Effect of pH

Stable and effective over pH 3 – 8 and well suited to neutral-pH rinse-off systems. Above pH 8 the isothiazolinone component hydrolyses and activity falls, so keep the finished product below pH 8.

Compatibility

Fully effective in anionic, cationic and non-ionic systems and compatible with most raw materials used in rinse-off and home care products. Avoid strong oxidising and reducing agents, sulphites and bisulphites, amines and other nucleophiles, which deactivate isothiazolinones.

Europe

• CMIT / MIT (3 : 1) is listed in Annex V, entry 39 of Regulation (EC) No 1223/2009, rinse-off only, at a maximum of 0.0015 % in the finished product
• DMDM Hydantoin is listed in Annex V at a maximum of 0.6 %
• Not permitted in leave-on cosmetic products
• Maximum recommended EsoDant 510 use level: 0.40 %

Americas

• Rinse-off: maximum 0.6 % DMDM Hydantoin and 0.0015 % CMIT / MIT
• Leave-on: maximum 0.6 % DMDM Hydantoin and 0.00075 % CMIT / MIT

Asia

• Japan – rinse-off: maximum 0.3 % DMDM Hydantoin and 0.01 % CMIT / MIT
• Japan – leave-on: not permitted, nor in oral hygiene or lip products, nor in preparations for children under three years of age

Home Care

• Notified under BPR (EU) No 528/2012, Product Type 6 (in-can preservatives)

Regulations are subject to revision. Confirm the status of each component against current local regulation before placing a finished product on the market.

The two actives cover the full USP <51> and EP 5.1.3 panel – P. aeruginosa, E. coli, S. aureus, C. albicans, A. brasiliensis – and reach formaldehyde-resistant strains. Recommended use levels are guideline starting points; establish preservative efficacy in the final formulation by challenge testing.

Store in a cool, dry place away from heat and direct sunlight, in tightly closed original containers. Shelf life 12 months from the date of manufacture when stored as directed.

EsoDant 510 contains isothiazolinones, which are skin sensitisers, and releases formaldehyde in use. Handle with appropriate personal protective equipment and avoid contact with skin and eyes. Please refer to the Safety Data Sheet (SDS).